STUDY ON THE MECHANISMS OF ABNORMAL SPA EXPRESSION AFTER SMOKE INHALATION INJURY
- VernacularTitle:烟雾吸入性肺损伤肺泡表面活性物质结合蛋白A表达异常机制的研究
- Author:
Zuhong FU
;
Zongcheng YANG
;
Zhenhon HU
- Publication Type:Journal Article
- Keywords:
acute lung injury;
pulmonary surfactants;
gene expression;
regulation
- From:
Medical Journal of Chinese People's Liberation Army
1981;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
The aim of this study was to investigate the mechanism of abnormal SPA expression after smoke inhalation injury (SII).The rat model with SII was used to observe the expression of SPA and the level of H 2 O 2 in the lung tissue. EMSA was performed to study the effect of H 2 O 2 on the TTF 1 binding activity in regulating area of SPA gene. The results showed that H 2 O 2 was increased, and the expression of SPA was down regulated in lung tissue after smoke inhalation injury. H 2 O 2 could inhibit the TTF 1 binding activity in SPA regulating area in vitro . Our results suggested that the inhibition of TTF 1 activity by oxidative stress might be the mechanism of abnormal SPA expression after SII.
