ANALYSIS OF PLATELET ACTIVATION AND ITS CLINICAL SIGNIFICANCE IN OLDER HYPERTENSIVE PATIENTS
- VernacularTitle:老年高血压患者血小板活化检测及临床意义
- Author:
Liping ZHANG
;
Guoshu LIU
;
Yingxian FAN
- Publication Type:Journal Article
- Keywords:
aged;
hypertension;
platelet activation
- From:
Medical Journal of Chinese People's Liberation Army
1981;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the changes of activated platelet marker and its significance in older hypertensive patients, glycoprotein Ⅱb/Ⅲa(PAC 1)and P selectin(CD62P) were used as molecular markers for activated platelets,which were analyzed by flow cytometric 3 color immunofluorescence. The results showed that PAC 1 expression on platelet membrane surface in older hypertensive patients was higher than that in healthy individuals and was not related with mean blood pressure.However, the expression of CD62P on platelets membrane surface did not differ in the two groups.These results suggest that PAC 1 may be regarded as a sensitive and specific molecular marker for activated platelets. Platelet activation occurrs in older hypertensive patients, and is of great importance for the antiplatelet therapy in hypertensive patients.
