The expression of MMP-9 in bronchial biopsy mucosal tissue in asthmatic subjects
- VernacularTitle:支气管哮喘患者气道粘膜活检组织MMP-9表达的临床研究
- Author:
Zhaosheng HAN
;
Jun XU
;
Shiyue LI
- Publication Type:Journal Article
- Keywords:
Bronchial asthma Airway epithelium MMP 9 Eosinophil Airway hyperresponsiveness
- From:
Chinese Journal of Practical Internal Medicine
2001;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of Matrix Metalloproteinase 9 (MMP 9) in bronchial biopy mucosal tissue and its relation to airway eosinophilic infiltration,lung function and airway hyperresponsiveness.Method 10 subjects with asthma were enrolled,meanwhile,10 healthy subjects and 6 subjects with COPD were as controls.At the same time,immunohistochemistry was employed.Results Immunohistochemistry for MMP 9 was positive in all asthmaticus,and just as such in 2/6 subjects with COPD.On the contrary,immunohistochemistry for MMP 9 was negative in all healthy subjects.The amount of MMP 9 expression was positively correlated with the number of eosinophil infiltrated to airway (r=0 62,P
