APOPTOSIS OF PERIPHERAL LYMPHOCYTE IN RADIATION COMPOUND WOUND HEALING AND ITS RELATIONSHIP TO DELAYED-WOUND HEALING
- VernacularTitle:放射复合伤口愈合中外周血淋巴细胞凋亡及其与愈合延迟的关系
- Author:
Yufang CUI
;
Guowei XIA
;
Xiaobin FU
- Publication Type:Journal Article
- Keywords:
radiation injuries;
lymphocyte;
apoptosis;
wound healing;
protein, Bax;
protein, Bcl 2
- From:
Medical Journal of Chinese People's Liberation Army
1983;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
To study the apoptotic regularity of peripheral lymphocytes in radiation compound wound healing and explore their relationship to radiation delayed wound healing, apoptosis and Bax and Bcl 2 proteins were estimated by in situ terminal labeling (TUNEL) and immunohistochemical method of alkaline phosphatase, respectively. White blood cells in radiation compound wound(RW) group decreased and reached the lowest 3 days after wound, it was still lower in RW group than in simple wound(SW) group 5 days after wound; apoptosis of peripheral lymphocytes of both groups increased, however, the lymphocyte apoptosis in RW group was higher than that in SW from beginning to end in the whole process of wound healing; the expression of Bax protein of lymphocyte increased at different times after wound, and the expression in RW group was obviously higher than that in SW group, while Bcl 2 showed an opposite tendency. It is suggested that reduction of white blood cells and increment of lymphocyte apoptosis are the major causes of radiation delayed wound healing; Bax and Bcl 2 proteins take part in the regulation of lymphocyte apoptosis in wound healing.
