IMPACTS OF HIGH SALT INTAKE PLUS COLD STRESS ON CARDIAC RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM IN RATS
- VernacularTitle:高盐和冷应激对大鼠心肌肾素血管紧张素醛固酮系统的作用
- Author:
Ziqiang WU
;
Shanjun ZHU
;
Zhimin ZHU
- Publication Type:Journal Article
- Keywords:
sodium chloride, dietary;
stress;
renin angiotensin system;
hypertension
- From:
Medical Journal of Chinese People's Liberation Army
1983;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
To study the effects of high salt intake together with cold stress on rat cardiac renin angiotensin aldosterone system (RAAS) in rats. Male Wistar rats were randomly divided into four groups: control, high salt (8%NaCl), cold stress (5 2℃) and compound group (8%NaCl+cold stress). Blood pressure and body weight were measured once a week. The experiment ran for 8 weeks. Renin activity (RA), angiotensinⅡ (AngⅡ), and aldosterone (Aldo) in plasma and left ventricle were determined with radioimmunoassay. Angiotensin II receptor mRNA was determined with RT PCR. The results showed that ①Rats in compound group had higher blood pressure than rats in the other three groups ( P
