Progress in mesenchymal stem cells as a novel nano-targeted antitumor drug carrier
10.3760/cma.j.issn.1673-4181.2013.03.001
- VernacularTitle:间充质干细胞作为新型纳米靶向抗肿瘤药物载体的研究进展
- Author:
Zhongyuan WANG
;
Yanping WU
;
Lin MEI
- Publication Type:Journal Article
- Keywords:
Mesenchymal stem cells;
Nano-carrier;
Tumor therapy;
Active target
- From:
International Journal of Biomedical Engineering
2013;36(3):129-133,后插2
- CountryChina
- Language:Chinese
-
Abstract:
In recent years,targeted drug delivery system as one of the hottest areas in pharmaceutical research has received more and more attention.However,the targeted anti-tumor drug delivery system has many shortcomings including low targeted efficiency which limit its clinical application.Elevating tumor targeting efficiency has become the bottleneck of nano-drug development and clinical application.Therefore,it is urgent to design and develop novel targeted drug delivery vehicle.Recent studies showed that mesenchymal stem cells (MSCs) have characters of tumor tropism and migration,which make them as ideal targeted anti-tumor drug delivery carriers for the treatment of solid and metastatic tumors.This paper reviews the progress in using MSCs as targeted anti-tumor drug delivery carrier,recapitulates the problems and challenges of the system,and proposes a solution for these problems.
