THE INFLUENCE OF RECOMBINANT HUMAN LIVER REGENERATION AUGMENTER ON SERUM CONCENTRATION OF HYALURONIC ACID IN EXPERIMENTAL LIVER FIBROSIS
- VernacularTitle:重组人肝再生增强因子对实验性肝纤维化血清透明质酸浓度的影响
- Author:
Aimin WANG
;
Fengting ZUO
;
Wenx WANG
- Publication Type:Journal Article
- Keywords:
liver cirrhosis;
hyaluronic acid;
recombinant human augmenter of liver regeneration
- From:
Medical Journal of Chinese People's Liberation Army
1983;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
In order to investigate the influence of recombinant human liver regeneration augmenter (hALR) on serum hyaluronic acid content in the process of experimental liver fibrosis, two kinds of animal models of rat experimental liver fibrosis induced by CCl 4 and albumin were established and different dosages of hALR were given during establishing the model. Serum specimens were obtained in different period of model establishment, and hyaluronic acid content was measured by radioimmunoassay (RIA). Results showed that in both rat models of experimental liver fibrosis, serum hyaluronic acid content in two hALR treatment group was significantly lower than that in different periods of model establishment. Serum concentration of hyaluronic acid in large dose of hALR treatment group was also significantly lower than that in low dose of hALR treatment group. These results indicate that recombinant human liver regeneration augmenter may decrease serum hyaluronic acid content in experimental liver fibrosis.
