Resistance to erythromycin and resistance phenotypes of Streptococcus pneumoniae
- VernacularTitle:肺炎链球菌对红霉素的耐药性及耐药表型
- Author:
Minggui WANG
;
Demei ZHU
;
Weihong WU
- Publication Type:Journal Article
- Keywords:
Streptococcus pneumoniae;
Erythromycin;
Clindamycin;
Drug tolerance;
Phenotype
- From:
Chinese Journal of Infectious Diseases
2000;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate bacterial resistance of Streptococcus pneumoniae against erythromycin and clindamycin, and resistance phenotypes of erythromycin resistant S. pneumoniae. Methods The MICs of erythromycin and clindamycin against 345 strains of S. pneumoniae were tested with agar dilution method, the phenotypes of erythromycin resistant S. pneumoniae were detected by double disc test. Results The resistance rates of S. pneumoniae to erythromycin and clindamycin were 53.0%(183/345) and 49.6%(171/345), respectively. Among erythromycin resistant S. pneumoniae , the percentages of cMLS, iMLS and M phenotype were 90.3% (159/176), 5.7% (10/176) and 4.0%(7/176), respectively. Conclusions The resistance rate of S.pneumoniae against erythromycin is very high in Shanghai. The main phenotype is cMLS.
