Observation on serology and histology of patients with chronic hepatitis B after interferon treatment
- VernacularTitle:干扰素治疗前后慢性乙型肝炎患者的血清学和组织学观察
- Author:
Zhenwei LANG
;
Honglei HAN
;
Dejun XU
- Publication Type:Journal Article
- Keywords:
Hepatitis B, chronic;
Interferon Alfa 2b;
Immunity;
Immun histochemistry;
Astrocytes;
Tissue inhibitor of metalloproteinase 1
- From:
Chinese Journal of Infectious Diseases
2000;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes in serology and liver histology of patients with chronic hepatitis B after interferon treatment. Methods Twenty four patients with chronic hepatitis B were enrolled in this research. Sera of patients were obtained before and after interferon treatment respectively. Liver biopsy was performed in each patient before and after treatment respectively. Serum ALT, HBsAg, HBcAg, HBeAg, HBV DNA and TIMP 1 were evaluated, as well as HAI(histological activity index), HBsAg, HBcAg, HBeAg, TIMP 1 and activated HSC in liver. Results The patients responded to interferon accounted for 7/24(37.5%). Compared with pretreatment, the serum HBV DNA and TIMP 1 decreased significantly( P
