The clinical effect of α1-antitrypsin gene therapy in treating diabetes
10.3760/cma.j.issn.1008-6706.2013.12.033
- VernacularTitle:α1-抗胰蛋白酶基因治疗糖尿病疗效观察
- Author:
Jianjun LI
- Publication Type:Journal Article
- Keywords:
Diabetes,1 type;
Gene therapy;
Stem cell transplantation;
Alpha 1-antitrypsin
- From:
Chinese Journal of Primary Medicine and Pharmacy
2013;20(12):1834-1836,1923
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical effect of α1-antitrypsin gene therapy in the treatment of diabetes.Methods 81 cases with type 1 diabetes were randomly divided into conventional treatment group,islet stem cell transplantation group and gene therapy group,27 cases in each group.The conventional treatment group received the insulin therapy,the stem cell transplantation group received the islet cell transplantation,and the gene therapy group received stem cell therapy of α1-antitrypsin gene.The clinical effect of these three groups were observed.Results The insulin concentration of the gene therapy group was significantly higher than the islet stem cell transplantation group and the conventional treatment group at five time points(F =1 349.379,1 831.186,1 068.173,416.080,257.810,all P ＜0.05).The glucose concentration of the gene therapy group was significantly lower than the other two groups at six time points (F =1 212.243,586.057,962.495,582.887,650.015,1 181.808,all P ＜ 0.05).The degree of inflammatory cell infiltration in the gene therapy group was significantly lighter than in the islet stem cell transplantation group.Conclusion α1-antitrypsin gene therapy can significantly improve the therapeutic effect of diabetes,which is worthy of clinical application.
