Pharmacokinetic study on flomoxef in healthy volunteers
- VernacularTitle:氟氧头孢健康人体内药代动力学研究
- Author:
Zhen LI
;
Ronglin YAN
;
Guilan JIN
;
Jinhong HU
- Publication Type:Journal Article
- Keywords:
flomoxef;
pharmacokinetics;
chromatography, high performance liquid
- From:
Academic Journal of Second Military Medical University
1981;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the pharmacokinetics of f1omoxef(Fmox) in 8 hea1thy volunteers after infusion of 1 gFmox injection. Methods: Fmox concentrations in plasma and urine were measured by an improved HPLC method. Results:The results showed that peak plasma level (cmax), terminal phase plasma elimination half-life (t1/2?), volume of distribution(Vc ), clearance (CI3)and area under plama concentration-time curve (AUC)were (56.15?13.16) ?g/ml, (1.29?0.32) h,(13. 11?12. 06) L, (16.02?1.88) L/h and (64.86?4.93)?g? h/ml respectively. Conclusion: Drug concentrations-time pro-file of Fmox conforms to a two-compartment open phartnacokinetic model. Fmox is mainly excreted through kidney in un-changed form. The cumulative urinary excretive rate of Fmox is (79. 39l4. 01) % 8 h after administration.
