Preliminary study on levels of IL-4,IL-12 and IgE in children with bronchial asthma
10.3969/j.issn.1000-3606.2001.01.003
- VernacularTitle:哮喘患儿IL-4、IL-12与IgE水平的初步研究
- Author:
Li ZHAO
;
Xiandi MAI
;
Weiping TAN
;
Huarong HUANG
;
Shaoliang HUANG
;
Changguo ZHU
- Publication Type:Journal Article
- From:
Journal of Clinical Pediatrics
2001;(1):9-10,40
- CountryChina
- Language:Chinese
-
Abstract:
In this study,IL-4 and IL-12 levels in plasma and peripheral blood mononuclear cells(PBMC) as well as serum IgE level were prospectively assessed with double-antibody sandwich ELISA technique in children with asthma during the attack group (30 cases)and the interval group(12 cases).The results observed revealed that serum IgE level and IL-4 level in plasma and PBMC after PHA and LPS provocation during both of the attack stage and the interval stage were found to be evidently higher than those of the normal control group (P＜0.01).Otherwise,IL-12 level during both stages was much lower than that of the normal control(P＜0.01).In other hand,there were found to have a significant difference in all these 3 data between attack and interval stages.Thus, the conclusion indicates that there might be an imbalance of IL-4,IL-12 and IgE level in children with asthma during both of the attack and the interval stages.
