Protective effects of imipramine on ischemic injury in cultured rat cerebral neurons
- VernacularTitle:米帕明对大鼠皮层神经细胞缺血性损伤的保护作用
- Author:
Yong XU
;
Biansheng JI
;
Yuan GAO
;
Hong LIU
;
Qingrong XU
;
Guiqin ZHANG
- Publication Type:Journal Article
- Keywords:
imipramine;
glutamate;
cortical neuron;
cell culture;
sodium dithionite;
cerebral ischmia
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2000;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the protective effects of Imipramine (Imi) on ischemic injury in cultured rat cerebral cortical neurons. METHODS: Cortical neurons of fetal rat were cultured in vitro. The protective effects of Imi on ischemic injury in cultured rat cerebral neurons were observed. RESULTS: Imi ( 10 -5, 10 -6, and 10 -7 mol?L -1) reduced the number of cell death, lowered LDH,NO,and MDA content, and increased of activity of SOD. CONCLUSION: Imi can protect rat cerebral cortical neurons from ischemic injury and toxicity of Glu. And it maybe attribute its to antioxidation and calcium antagonism.
