Effect of ligustrazine on the calcium contants and calmodulin activity of lung tissue in rats of the bleomycin-induced pulmonary fibrosis
- VernacularTitle:川芎嗪对鼠肺纤维化组织钙含量及钙调素活性的影响
- Author:
Juyuan LIU
;
Yongfen CHEN
- Publication Type:Journal Article
- Keywords:
oigustrazine;
pulmonary fibrosis;
calcium contents;
calmodulin activity
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2000;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To observe the effect of ligustrazine on the calcium contents and calmodulin activity of lung tissue in rats of the bleomycin-induced pulmonary fibrosis. METHODS: Thirty-two SD rats were replicated into pulmonary fibrosis models by intratracheal injection of bleomycin A 5 in one lump and were divided into two groups randomly, untreated model group (n=16) and ligustrazine group(n=16). The calcium contents and calmodulin activity of the lung of the rats of each group were assayed on d 14, d 28 after the injection and compared with control group (n=8). RESULTS: The calcium contents and calmodulin activity of model group were obviously higher than control group (P
