Combination effect of captopril and losartan on cell adhesion molecules and cytokines in the patients with coronary heart disease
- VernacularTitle:卡托普利与氯沙坦合用对冠心病患者血液细胞因子的影响
- Author:
Xuguo LIANG
;
Qixin PAN
- Publication Type:Journal Article
- Keywords:
captopril;
losartan;
cell adhesion molecules;
cytokins;
coronary heart disease
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2000;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To explore the effect of the combination of captopril and losartan on the sICAM-1, sVCAM-1, TNF-?, and TGF-? in the patients with coronary heart disease. METHODS: sICAM-1, sVCAM-1 and TGF-? were measured with ELISA, and TNF-? was measured with RIA in the patients with or without the treatment of captopril and losartan. RESULTS: sICAM-1 and TNF-? decreased, and TGF-? increased distinctly in the patients given a combination of captopril and losartan compared with patients without the drugs. sVCAM-1 had the tendency of decrease in combined therapy, but no significant difference showed compared with the control patients. CONCLUSION: The combination of captopril and losartan has the effects on the cell adhesion molecules and cytokins in patients with coronary heart disease.
