Effects of liqustraxin on dysfunction of myocardial nuclear calcium transport
- VernacularTitle:川芎嗪对心肌细胞核钙转运功能异常的保护
- Author:
Lamei XIA
;
Jiexion WU
- Publication Type:Journal Article
- Keywords:
liqustraxin;
Ca 2+transport;
Ca 2+-ATPase;
nucleus/myocardium
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2000;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To observe the dysfunciton of myocardial nuclear calcium transport in rat myocardial injury and the effects of liqustraxin on it. METHODS: The model of myocardial damage was induced by subcutaneous injection of isoproterenol (ISO,5 mg?kg -1?d -1). Myocardial nuclei were purified with sucrose density centrifugation and identified zymologically. The activity of Ca 2+-ATPase was measured zymologically and calcium uptake was assayed with 45Ca 2+ isotope. RESULTS: Compared with the control,the Ca 2+-ATPase activity of myocardial nuclear membrane in ischemia group(exprimental) was decreased by 18.1% (P
