ROLE OF ADHESIVE MOLECULES IN MEDIATING HEMATOGENOUS METASTASIS OF DIFFERENT LUNG CARCINOMA CELL LINES AND THE REGULATION EFFECT OF TEA POLYPHENOLS
- VernacularTitle:粘附分子在肺癌血行转移中作用及茶多酚的调控研究
- Author:
Qingyong CHEN
;
Yuquan WU
;
Xiaoxia JIANG
- Publication Type:Journal Article
- Keywords:
lung neoplasms;
intercellular adhesion molecule 1;
tea polyphenols
- From:
Medical Journal of Chinese People's Liberation Army
1981;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Confocal microscope and flow cytometry were used to study the adhesion and the expression of adhesive molecules between different metastatic lung cancer cells and endothelial cells (EC) in vitro. Tea polyphenols (TP) were tested for their effect on tumor cell endothelial adhesion.The results showed that the adhesion and expression of CD44?CD54 were significantly higher in PG cells than those in D9 cells. Treatment of EC monolayers with LPS(0 5ug/ml) for six hours caused an increase in adhesion of PG to EC and adhesive molecules expression. TP could inhibit the adhesion of PG to EC and expressions of CD44 and CD54 in dose dependent manner. It suggested that adhesion molecules might play an important role in mediating the adhesion of lung carcinoma to EC and hematogenous metastasis; TP had an inhibitory effect on metastasis of lung cancer.
