ACUTE AND LATE SIDE-EFFECTS OF AUTOLOGOUS PERIPHERAL BLOOD STEM CELL TRANSPLANTATION IN PEDIATRIC PATIENTS
- VernacularTitle:小儿自体外周血造血干细胞移植近期和远期毒副作用的研究
- Author:
Jianwen WANG
;
Chenjie TIAN
;
Suoqi TANG
- Publication Type:Journal Article
- Keywords:
hematopoietic stem cell transplantation;
transplantation, autologous;
follow up studies
- From:
Medical Journal of Chinese People's Liberation Army
1981;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the acute and late side effects of autologous peripheral blood stem cell transplantation (Auto PBSCT) in children. Acute toxicity was evaluated in 21cases, according to Beurmen criteria. 11 patients who lived longer than 3 years after Auto PBSCT were followed up. Acute toxicity was mild. Growth and neuropsychological development were normal. Two children developed slight compensated hypothyroidism. Puberty was delayed in one male patient. Mild cataract was noticed in six children. Seven patients were found to suffer from hepatitis. The results suggested that pediatric patients were able to tolerate an appropriate pre conditioning regimen. Attention shoud be paid to the prevention of hepatitis.
