Concentration of hyaluronic acid in peritoneal fluid in patients with gastric carcinoma and its clinical significance
- VernacularTitle:胃癌患者腹腔液中透明质酸的分泌水平及其临床意义
- Author:
Yang LI
;
Qiang WANG
- Publication Type:Journal Article
- Keywords:
stomach neoplasm;
hyaluronic acid;
neoplasm metastasis;
peritoneal fluid
- From:
Academic Journal of Second Military Medical University
1981;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the relationship between the level of hyaluronic acid(HA) in peritoneal fluid in patients with gastric cancer and the invasion or diffusion of the cancer. Methods: The concentration of peritoneal fluid hyaluronic acid (PFHA) was determined by RIA in 48 patients with gastric cancer prior to and after operation. The PFHA from 23 non carcinoma patients were taken as control. The peritoneal fluid was obtained by the implantable Infuse Port. Results: The average PFHA level of gastric cancer group[(913.01?170.69) ?g/?g] was significantly higher than that of the non carcinoma control [(362.39?168.82) ?g/?g]. The PFHA concentration were significantly higher in groups of pTNM Ⅲ+Ⅳ [(1 094.42?127.65) ?g/?g] than that in groups of pTNM Ⅰ+Ⅱ [(814.03?232.22) ?g/?g]. The PFHA level in the radical resection group was significantly reduced a month after operation, and there were no significantly changes in patients received palliative resection. Conclusion: These findings suggest that the elevation of PFHA may be related to the peritoneal invasion and diffusion potential of gastric cancer. The PFHA level shows a decreasing tendency in patients received radical resection.
