Dynamic change in learning and memorising ability after hemispheric irradiation in rats
- VernacularTitle:半脑照射后大鼠学习记忆力损伤特点及其变化规律
- Author:
Xuezhong LI
;
Shiyao BAO
;
Kangren ZHAO
;
Yie TIAN
;
Zhilin ZHANG
- Publication Type:Journal Article
- Keywords:
Electron irradiation;
Cerebral hemisphere;
Learning, memorizing ability;
Rat
- From:
Chinese Journal of Radiation Oncology
1992;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the sequence of learning and memory loss in the rat after hemispheric irradiation. Methods After Sprague Dawly(SD) female rats were anaesthetized with chloral hydrate, their cerebral hemispheres were irradiated with a single dose of 5,15 or 30?Gy by 4?MeV electron. On D3,D7,D30 and D60, the learning and memorizing ability was measured with the Y maze test. Results On D3 and D7, the learning ability of SD rats was impaired most but partly restored in 1 to 2 months. In observation of memory loss, the intensity of cerebral function damage was in direct proportion to the increase of radiation dose.Conclusion The learning and memorizing ability of rats can be damage by hemispheric irradiation with the severity of impairment and possibility of recruitment depending on the dose.
