CHANGES IN ACTIVITY OF THE 26S PROTEASOME AND 19S REGULATOR IN SKELETAL MUSCLE OF SEVERELY SCALDED RATS
- VernacularTitle:严重烫伤大鼠骨骼肌26S蛋白酶复合体和19S调节复合体活性的变化
- Author:
Yinling TAN
;
Shiliang WANG
;
Yanlin DONG
- Publication Type:Journal Article
- Keywords:
burns;
26S proteasome;
19S regulator
- From:
Medical Journal of Chinese People's Liberation Army
1982;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
To elucidate the mechanism of negative nitrogen balance after burns, immuno precipitation deduction was used to observe the changes in the activity of 26S proteasome and 19S regulator in skeletal muscle of rats inflicted with 30%TBSAⅢ o burns. The protease activity, ATPase activity of 26S proteasome,as well as 19S regulator in skeletal muscle of rats were markedly enhanced on the second day after scald. It is suggested that burn injury could activate the 26S proteasome in skeletal muscle, in turn enhance the degradation of protein , which is associated with negative nitrogen balance following scald
