THE INHIBITORY EFFECT OF CYCLOSPORIN A ON THE EXPRESSION OF NITRIC OXIDE SYNTHASE FOLLOWING CONCANAVALIN A INDUCED LIVER INJURY IN MICE
- VernacularTitle:环孢霉素A阻断刀豆蛋白A肝损害肝细胞表达一氧化氮合酶的研究
- Author:
Xiuli ZHANG
;
Qizhen QUAN
;
Ziqi SUN
- Publication Type:Journal Article
- Keywords:
cyclosporine;
nitric oxide synthase;
liver injury
- From:
Medical Journal of Chinese People's Liberation Army
1982;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
This study was to study the effect of cyclosporine A (CsA) on the expression of nitric oxide synthase (NOS) in liver cells in T cell dependent liver injury induced by concanavalin A (ConA) in mice. The results showed that there was no NOS expression in the normal murine hepatocytes. Affer ConA challenge, the expression of NOS in hepatocytes increased markedly.Moreover, the hepatocytes closer to the central vein showed stronger expression.After pretreatment of CsA, activation of T lymphocytes was inhibited and NOS expression in the hepatocytes was almost completely inhibited too.The above results suggest that an upregulation of NOS expression might be a protective response to insufficient supply of blood and oxygen as a result of ConA induced liver injury, and inhibition of the NOS expression by CsA might be associated with inactivation of T lymphocyte.
