Effect of neferine on intracellular adriamycin accumulation in MCF-7/Adr cell line
- VernacularTitle:甲基莲心碱对耐阿霉素人乳腺癌细胞内阿霉素积累的影响
- Author:
Ling DONG
;
Xiaoqing TANG
;
Jianguo CAO
;
Zuo WANG
- Publication Type:Journal Article
- Keywords:
neferine;
multidrug resistance;
Adriamycin
- From:
Chinese Pharmacological Bulletin
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the effect of neferine on intracellular adriamycin(ADM) accumulation in MCF-7/Adr cell line. METHODS The cytotoxic effect was determined by MTT assay. The intracellular ADM concentration was assayed by HPLC. RESULTS Neferine(Nef) decreased the IC 50 of ADM to MCF-7/Adr cells but increased the intracellular concentration of ADM. CONCLUSION The mechanism of the MDR reversal effect of Nef is associated with the increase of the intracellular accumulation of anticancer drug.
