Effect of melatonin on blood pressure and aortic relaxation and contraction activity from hypertensive rats
- VernacularTitle:褪黑素对肾血管型高血压大鼠的血压及主动脉舒缩功能的影响
- Author:
Yusheng WEI
;
Rende LI
- Publication Type:Journal Article
- Keywords:
melatonin;
renovascular hypertention;
thoracic aorta;
isolated vessel ring
- From:
Chinese Pharmacological Bulletin
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To observe the hypotensive effect of melatonin (MT) on two-kidney one-clip renal hypertensive (2K1C) rats and to explore its aortic mechanism. METHODS 2K1C rats were obtained by narrowing the left kidney artery; systolic blood pressure was measured by use of tail-cuff method; vascular actions of MT were measured using isolated blood vessel method. RESULTS MT reduced blood pressure of 2K1C rat significantly 〔(23.45?2.40) kPa versus (19.81?2.78) kPa, P
