Experimental research of sodium gamma-hydroxybutyrate on cerebral ischemia-reperfusion injury in gerbils
- VernacularTitle:羟丁酸钠对沙土鼠脑缺血再灌注损伤的作用研究
- Author:
Jing ZHANG
;
Jidong GUO
;
Shuling GU
;
Tijun DAI
;
Shiming DUAN
- Publication Type:Journal Article
- Keywords:
sodium gamma-hydroxybutyrate;
cerebral ischemia-reperfusion injury;
gerbil;
Na +,K +-ATPase;
Ca 2+ -ATPase;
superoxide dismutase;
malondialdehyde
- From:
Chinese Pharmacological Bulletin
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To investigate the protective effect of sodium gamma-hydroxybutyrate (?-OH) against cerebral ischemia-reperfusion injury in gerbils and the neuroprotective mechanism of ?-OH. METHODS The occlusion of bilateral carotid arteries of gerbil was used to make the cerebral ischemia-reperfusion models. Different doses of ?-OH were administered intraperitoneally 40 min prior to the onset of ischemia. After 10 min ischemia and 1 h reperfusion, bilateral hippocampus, cortex and striatum were taken out to measure ATPase, SOD and MDA. RESULTS The contents of MDA markedly elevated while Na +,K +-ATPase, Ca 2+ -ATPase and SOD activities decreased in hippocampus, cortex and striatum 1 h after ischemia-reperfusion. ?-OH administered prior to ischemia can partly reverse the elevation of MDA contents and the reduction of SOD activities. ?-OH given after ischemia can still provide partly protective effect. CONCLUSION ?-OH provides significant protective effect against cerebral ischemia-reperfusion injury by protecting ATPase and SOD activities, deleting free radicals and reducing the lipid peroxidation.
