Effect of different IBMX level on cGMP and GFAP production in the gerbil hippocampus
- VernacularTitle:不同浓度的IBMX对海马区cGMP及GFAP合成的影响
- Author:
Jingjun ZHANG
;
Dongmei HU
;
Tianfu LI
- Publication Type:Journal Article
- Keywords:
cGMP;
cerebral ischemia;
hippocampus;
astrocyte
- From:
Chinese Pharmacological Bulletin
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To observe effects of IBMX on cGMP and GFAP production in gerbil hippocampus after recirculation following ischemia. METHODS Bilateral occlusion of common carotid arteries and immunofluorescent stain methods in gerbil hippocampal tissue slice were used. RESULTS Recirculation following ischemia leads to a rise in hippocampus cGMP and GFAP concentration. cGMP and GFAP positive cells mainly distributed in rediatum layer and molecular layer in the CA 1 subfield, Most of cGMP positive cells are astrocytes under double immunofluorescent stain. Most of cGMP strong positive cells are also those of GFAP strong positive cells. IBMX increased cGMP and GFAP production. CONCLUSION cGMP is possible to play an important role in the activation or regulation of GFAP in the hippocampus.
