Inhibition of topiramate on amygdala kindling in rats
- VernacularTitle:托吡酯对大鼠杏仁核点燃的抑制作用
- Author:
Ming ZHOU
;
Yanxia LIU
;
Zhihong YANG
;
Shenbo GUO
;
Boqin SHAO
;
Wang YUE
- Publication Type:Journal Article
- Keywords:
topiramate;
amygdala kindling;
valproate sodium;
nicardipine;
epilepsy
- From:
Chinese Pharmacological Bulletin
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To investigate the role and mechanism of a novel antiepileptic drug topiramate on amygdala kindling in rats. METHODS The effects and mechanism of topiramate on kindling were examined by the establishment of amygdala kindling model and combination with other drugs. The influence of topiramate on seizures induced by semicarbazide hydrochloride(SCZ) was also observed. RESULTS Topiramate (50～200 mg?kg -1 ,ig) dose-dependently inhibited the seizure severity in amygdala kindling ( P
