Correlation Between the Expression of Epidermal Growth Factor Receptor and MR Features in Glioma.
- Author:
Bum Soo KIM
;
Kyung Sub SHINN
- Publication Type:Original Article
- MeSH:
Astrocytoma;
Brain;
Edema;
Epidermal Growth Factor*;
Glioblastoma;
Glioma*;
Hemorrhage;
Humans;
Magnetic Resonance Imaging;
Necrosis;
Population Characteristics;
Receptor, Epidermal Growth Factor*;
Retrospective Studies
- From:Journal of the Korean Society of Magnetic Resonance in Medicine
1997;1(1):125-129
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The aim of this study was to find correlation between the expression of epidermal growth factor receptor (ECFR) and MR findings in the brain glioma. MATERIALS AND METHODS: MR features including edema, margin, necrosis, heterogeneity, hemorrhage and contrast enhancement were retrospectively analyzed with preoperative MR images in 41 patients with proven brain gliomas (8 low grade astrocytomas, 12 anaplastic astrocytomas, 21 glioblastoma multiformes). Immunohistochemical study of EGFR was done and their expressions were graded by both stained distribution and intensity. Correlation analysis between the MR features and EGFR expressions was done. RESULTS: Peritumoral edema was correlated with both distribution (r=0.71, p=0.00) and stain intensity (r=0.69, p=0.00) of EGFR expression. Other MR features showed no statistical correlation with EGFR expression. CONCLUSION: MRI is useful in evaluation of brain glioma, and peritumoral edema is useful findings that suggests EGFR expression as well as malignant histopathologic grade of the tumor.
