Effects of vitamin E on the expression of type Ⅰ collagen, TGF?_1 and TIMP_2 of hepatic stellate cells
- VernacularTitle:维生素E对肝脏星状细胞Ⅰ型胶原、TGF?_1和TIMP_2表达的影响
- Author:
Dedong XIANG
;
Qifen LI
;
Yuming WANG
- Publication Type:Journal Article
- Keywords:
Vitamin E;
Hepatic stellate cell;
Type Ⅰ collagen;
Tissue inhibitor of matrix metalloproteinase;
Transforming growth factor ? 1
- From:
Chinese Journal of Infectious Diseases
1999;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of vitamin E on type Ⅰ collagen, messenger RNA expression of transforming growth factor ? 1 (TGF? 1) and tissue inhibitor of matrix metalloproteinases-2 (TIMP 2) in hepatic stellate cells (HSC). Methods HSC s were cultured in vitro, the effect of vitamin E on type Ⅰ collagen was observed by mean of immunohistochemistry; mRNA expression of TGF? 1 and TIMP 2 were investigated with in situ hybridization. Results In experiment group, vitamin E markedly inhibited expression of type Ⅰ collagen of HSC as compared with control group, but could not suppress mRNA expression of TGF? 1 and TIMP 2.Conclusions Anti-fibrotic effect of Vitamin E may be implemented through inhibiting the expression of type Ⅰ collagen.
