Effects of LFN-? and IL-4 on MW-l? production in lupus nephritis
- VernacularTitle:干扰素-?和白细胞介素4对狼疮肾炎患者巨噬细胞炎症蛋白-1?产生的效应
- Author:
Daoyuan ZHOU
;
Youji LI
;
Jianqin WANG
;
At ET
- Publication Type:Journal Article
- Keywords:
Lupus nephritis;
Macrophage inflammatory protein-1?;
Interferron-?;
Interleukin-4
- From:
Chinese Journal of Nephrology
1997;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of IFN-? and IL-4 on MIP- ? production of peripheral blood mononuclear cells (PBMC) in lupus nephritis (LN) Methods MIP-1? expression in supematants was determined by Elisa and MLP-l? mRNA in PBMC was detected by RT-PCR. Results (1) IFN-? increased MIP-1? prouduction of PBMC in LN. (2) IL-4 inhibited MIP-1? production of PBMC in LN. (3) No significant effect on PBMC in controls was found by either IFN-? or IL-4. Conclusion IFN-? enhances MLP- 1? production of PBMC in LN wherease LL-4 inhibits it.
