Hyperhomocysteinemia in patients with chronic renal failure
- VernacularTitle:慢性肾功能衰竭患者的高同型半胱氨酸血症
- Author:
Yueming YU
;
Fanfan HOU
;
Xun ZHANG
- Publication Type:Journal Article
- Keywords:
Renal failure ,chronic;
Homocysteine;
Cardiovascular Disease;
Dialysis
- From:
Chinese Journal of Nephrology
1997;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate hyperhomocysteinemia in chronic renal failure (CRF), its prevalence, etiology and potential relationship to arteriosclerotic events. Methods Plasma total homocysteine (tHcy) was measured in 160 patients with CRF, 31 patients with coronary artery disease and 45 healthy controls by using fluorescence polarization immunoassay. Results Eighty-two percent of CRF patients had hyperhomocysteinemia compared to 22% in patients with coronary artery disease. Mean plasma tHcy level in heomodialysis (HD) patients [(24. 13 ?12. 68) ?mol/L] was significantly higher than that in continuous ambulatory peritoneal dialysis (CAPD) patients [(16. 43?5. 58) ?mol/L] and that in normal controls [(7. 97 ?2. 65)?mol/L] . Plasma tHcy level in dialysis patients with cardiovascular diseases [(27. 12 ?15. 94)?mol/L, n=30] was higher than that in those without clinical manifestation of these complications [(20. 17?8. 71) ?mol/L, n = 62] . The levels of tHcy correlated inversely with Ccr (r = -0. 374, P
