Antiproliferative effect of HMG CoA reductase inhibitor on ADPKD cyst-lining epithelial cell and its mechanism
- VernacularTitle:羟甲基戊二酰辅酶A还原酶抑制剂对多囊肾病囊肿衬里上皮细胞增殖抑制及其机制的研究
- Author:
Shouyi GE
;
Changlin MEI
;
Chenggang XU
- Publication Type:Journal Article
- Keywords:
Autosomal dominant polycystic kidney;
HMG CoA reductase inhibitor;
Proliferation;
p21 ras;
Cyst-lining epithelial cell
- From:
Chinese Journal of Nephrology
1997;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the antiproliferative effect of HMG CoA reductase inhibitor on ADPKD cyst-lining epithelial cells and its possible mechanism. Methods Cell viability was assayed by MTT. Membrane-bounded p2lras was detected by immunoblotting. The expression of c-jun and c-fos was examined by immunocytochemistry. Results After ADPKD cyst-lining epithelial cells were exposed to HMG CoA reductase inhibitor, proliferation was markedly inhibited( P
