The immune function injury and its mechanism in drug abuser
- VernacularTitle:药物滥用者机体免疫功能损伤机制探讨
- Author:
De HE
;
Fang LIU
;
Zhen GUO
- Publication Type:Journal Article
- Keywords:
drug abuse;
immune function;
subgroups of Th cells;
transformation of lymphocytes;
compliment;
cellular factor;
nitric oxide(NO)
- From:
Chinese Journal of Tissue Engineering Research
2002;6(19):2966-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the immune function injury and its mechanism in drug abuser.Methods The immune function changes in 50 drug abusers were compared with normal healthy populations by detection of the indexes of subgroups of Th cells, transformation rate of lymphocytes,IgA,IgM,IgG,IgE,compliment C3,C4,IL 1, IL 2,IL 6 TNF and NO.Result In peripheral blood the percentage of Th1 cell, transformation rate of lymphocyte, IgA, IgM, IgG, IgE content, compliment C4,C4, IL 1, IL 2,IL 6,and TNF levels were significantly lower than normal(P< 0.01).The value of Th1/Th2 was lower than normal as well(P< 0.05).NO content was significantly higher than normal(P< 0.001).Conclusion The mechanism of immune function injury in drug abuser might be correlative to direct injury of drugs and their inhibition effect on the thymus hypothalamus hypophysis adrenal axis.
