Arterial baroreceptor reflex dysfunction and target organ damage in spontaneously hypertensive rats
- VernacularTitle:动脉压力感受性反射功能受损与高血压靶器官损伤
- Author:
Zhengzheng SHAN
;
Shengming DAI
;
Dingfeng SU
- Publication Type:Journal Article
- Keywords:
arteries;
baroreceptor reflex;
blood pressure;
heart rate;
hypertension target organ damage
- From:
Academic Journal of Second Military Medical University
1982;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the correlation between arterial baroreceptor reflex (ABR) function and target organ dam age (TOD) in spontaneously hypertensive rats (SHR) .Methods:Twenty- four- hour blood pressure (SBP and DBP ) ,blood pressure variability (BPV ) ,heart rate (HR ) and HR variability (HRV ) were m easured in conscious, unrestrained SHR and Wistar- Kyoto (WKY ) rats.ABR function control of heart period (ABR- HP) and blood pressure (ABR- BP) were determined respectively.Hypertensive TOD was evaluated according to the scoring system.Results:SBP, DBP and their BPV were significantly increased in SHR compared with those of WKY rats.No difference of HR was found between the 2 strains,but HRV was significantly decreased in SHR when com pared with WKY rats.ABR- HP and ABR- BP of SHR were significantly decreased compared with those of WKY rats (P
