THE GENE HETEROGENEITY AND QUASISPECIES OF HEPATITIS B VIRUS IN PATIENTS WITH CHRONIC HEPATITIS B
- VernacularTitle:乙型肝炎病毒基因异质性及准种特点研究的临床意义
- Author:
Jun CHENG
- Publication Type:Journal Article
- Keywords:
hepatitis B virus;
genotype;
serotyping;
heterogeneity;
quasispecies;
mutation;
transactivation
- From:
Medical Journal of Chinese People's Liberation Army
1983;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Mutations of hepatitis B virus (HBV) viral genomes are normal biological events and result in the heterogeneity, such as coexistence of viral genotypes and serotypes in infected individuals('quasispecies'). The HBV DNA heterogeneity is ubiquitous all chronic HBV infected patients, and it involves each DNA fragment of both structural and regulatory genes. The process of heterogeneity is continuing,with important biological and clinical implications, playing an important role inthe pathogenesis, drug resistance, and even hepato carcinogenesis in hepatitis patients. The introduction of the conception of quasispecies may contribute to a revolutionary re evaluation of the mutations of HBV DNA.