EXPERIMENTAL STUDY OF MYOCARDIAL ISCHEMIA AND HEMODYNAMIC CHANGES DURING PULMONARY LOBECTOMY IN DOG WITH OR WITHOUT CORONARY ARTERY STENOSIS
- VernacularTitle:肺叶切除术对心肌血供及血流动力学的影响
- Author:
Li ZHANG
;
Shiwen WANG
;
Dalia LI
- Publication Type:Journal Article
- Keywords:
pneumonectomy;
myocardial ischemia;
hemodynamics;
radionuclide imaging
- From:
Medical Journal of Chinese People's Liberation Army
1983;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
To determine the effect of pulmonary lobectomy on myocardial blood supply and hemodynamics, 18 dogs were randomized into 3 groups. The dogs in group A and C were subjected to about 75% occlusion of the left anterior descending coronary artery. One week later, dogs in group C were sacrificed by arterial bleeding, while dogs in group A and B underwent right upper pulmonary lobectomy, and extremity ECG, blood routine, blood gas, hemodynamics and morphological changes of the myocardium were examined. The results showed that pulmonary lobectomy could result in or worsen myocardial ischemia. There was significant decrease in PO 2 , SaO 2 ; and CI, and significant elevation of LVEDP, PCWP and MPAP. There were more elevation of LVEDP and less decrease in CI after lobectomy in group A compared with group B. It suggested that pulmonary lobectomy could intensify myocardial ischemi and indace hemodynamic disturbances by lowering PO 2 and SaO 2 , especially where there was coronary artery stenosis before the operation.
