IN VIVO ~1H NMR SPECTROSCOPY IN RAT C6 GLIOMA
- VernacularTitle:脑胶质瘤模型在体~1H磁共振波谱研究
- Author:
Hong YIN
;
Zhilan HUANG
;
Yuangu GAO
- Publication Type:Journal Article
- Keywords:
rat;
glioma;
nuclear magnetic resonance;
spectroscopy
- From:
Medical Journal of Chinese People's Liberation Army
1983;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
By using the high magnetic field spectrometer to assess the practical value of 1 H NMR spectroscopy in vivo through observation of changes in metabolism of C6 glioma, fourty Wister rats were divided into two groups: ten as controls, and in thirty rats C6 glioma cells were implanted spheroids in right caudate nucleus. MR images were carried out at intervals. The 1 H NMR spectroscopy were performed by using point resolved spectroscopy (PRESS) technique. The NAA Cho, Cr+PCr, Glu+Gln, Lip, Lac were observed in normal rats. The NAA intensity was seen to be decreased or disappeared in C6 glioma, and NAA/Cho ratio and NAA/Cr ratio decreased obviously( P
