Expression of urotensinⅡreceptor GPR14 in cardiovasculature and brain of rats
- VernacularTitle:尾加压素受体GPR14在大鼠心血管系统及脑内的表达
- Author:
Ling LI
;
Wenjun YUAN
;
Jingwei QIU
;
Xiujie PAN
- Publication Type:Journal Article
- Keywords:
G-protein-coupled-receptor;
urotensins;
ventricle;
cerebellum;
polymerase chain reaction
- From:
Academic Journal of Second Military Medical University
1982;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the expression of the G-protein-coupled-receptor 14 (GPR14), urotensinⅡreceptor, in the cardiovascular system and brain of SD rats. Methods: Semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR) was used to detect the GPR14 mRNA. Results: In cardiovascular system, GPR14 mRNA was detected in the left ventricle, left atrium, thoratic aorta and carotid aorta. The highest level of expression was found in the left ventricle. In the brain, GPR14 mRNA was detected in cortex, hippocampus, hypothalamus and cerebellum, and higher level of expression was found in the cerebellum. Conclusion: GPR14 mRNA expression is found in the cardiovascular and neural tissues of tested rat, suggesting that urotensinⅡ may play an important role in cardiovasculature and central nervous activity.
