Molecular Mechanisms and Interference Strategies of Glaucoma and Myopia
- VernacularTitle:青光眼和近视眼的分子机制及干预研究
- Author:
Jian GE
- Publication Type:Journal Article
- Keywords:
glaucoma;
myopia;
mutation;
stem cells;
defocus
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2010;31(2):154-160,165
- CountryChina
- Language:Chinese
-
Abstract:
The paper briefly reports the preliminary research results,focusing on the pathogenesis,mechanisms and interference strategies of glaucoma and myopia.(1)The myocilin gene has been found a mutation in Pro370Leu in GZ.1 and PN.1 glaucoma pedigrees,and the theory of protein misfolding and mitochondria dysfunction in glaucoma was then firefly elucidated.We further explored the modulation of wound healing by siRNA,neuro-protection by targeting drugs with drug deliver system and stem cells/iPS in glaucoma therapy,which offer a revolutionary strategy for glaucoma:differential treatment for specific stages.(2)Natural myopia model was successfully established in rhesus monkeys and retinal mechanisms and central nervous system were both found to play an important role during myopia development,and a variety of new optical interventions were therefore employed on human beings by series of randomized,controlled,double-masked prospective clinical trials.All these preliminary results offer a new insight into the new model for the diagnosis and treatment of glaucoma and myopia.
