Preparation and evaluation of sustained-release polylactic acid microspheres of bupivacaine in vitro
- VernacularTitle:布比卡因聚乳酸缓释微球的制备及体外释药研究
- Author:
Yuan YU
;
Shen GAO
;
Yanqiang ZHONG
;
Xueying DING
- Publication Type:Journal Article
- Keywords:
bupivacaine;
microspheres;
in vitro;
delayed-action preparations
- From:
Academic Journal of Second Military Medical University
1982;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To prepare sustained-release polylactic acid microspheres containing bupivacaine (BUP-PLA-MS) and to measure its dissolution in vitro. Methods: BUP-PLA-MS was prepared with polylactic acid (PLA) as carriers using the water-in-oil-in-water (W/O/W) emulsion solvent evaporation method. The powder particle characteristics of BUP-PLA-MS were evaluated comprehensively, and its dissolution characteristics in vitro were studied. Results: It was indicated that bupivacaine formed molecular dispersion within PLA matrix by differential thermal analysis(DTA). The in vitro release behavior of bupivacaine could be best described by Higuchi equation, with t 1/2 =22.76 h. Conclusion: Release of bupivacaine from microspheres is sustained in vitro.
