INHIBITION OF VEGF EXPRESSION IN C_6 GLIOMA CELLS WITH VEGF ANTISENSE OLIGONUCLEOTIDES
- VernacularTitle:VEGF反义寡核苷酸对C_6胶质瘤细胞VEGF表达抑制作用的定量和定性检测
- Author:
Weifang LI
;
Guangji ZHANG
;
Chen ZHU
- Publication Type:Journal Article
- Keywords:
endothelial growth factor;
oligonucleotides, antisense;
glioma
- From:
Medical Journal of Chinese People's Liberation Army
1982;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
To observe the inhibition of vascular endothelial growth factor(VEGF) expression in C 6 glioma cells with VEGF antisense oligonucleotides.VEGF expression in C 6 glioma cells was examined quantitatively and qualitatively with immunofluorescence flow cytometric analysis and immunohistochemistry.Results showed that VEGF antisense ODNs inhibited the VEGF expression in C 6 glioma cells,and the inhibition was concentration dependent.This indicates that VEGF antisense ODNs can effectively suppress the VEGF expression in C 6 glioma cells.
