EXPRESSION OF INTERLEUKIN-1? CONVERTING ENZYME GENE IN CEREBRAL ISCHEMIA AND REPERFUSION
- VernacularTitle:白细胞介素-1?转化酶基因在脑缺血再灌注后的表达
- Author:
Jintao ZHANG
;
Weiping WU
;
Fengyin ZHANG
- Publication Type:Journal Article
- Keywords:
brain ischemia;
reperfusion;
apoptosis;
caspase 1;
gene expression
- From:
Medical Journal of Chinese People's Liberation Army
1982;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
mRNA and protein expression of interleukin 1? converting enzyme (ICE) were determined with RF PCR and immunohisto chemistry in brain tissue after complete ischemia followed by reperfusion of the forebrain of gerbil.The effect of radix salviae miltorrhizae was also studied. It was found that increased expression of ICEmRNA was induced during the 4 days after ischemia and reperfusion. Meanwhile, the increases in ICE positive reactivity were observed in glial cells in the regions of CA1 and cortex 1～4 days after ischemia and reperfusion, but the ICE positive reaction was inhibited under the effect of radix salviae miltiorrhizae(P
