A new target for anti-ischemic drugs: mitochondrial ATP-sensitive potassium channel
- VernacularTitle:抗心肌缺血药物的新靶点:线粒体ATP敏感性钾通道
- Author:
Wei LIU
;
Hai WANG
- Publication Type:Journal Article
- Keywords:
ATP sensitive potassium channels;
mitochondria;
myocardial ischemia
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
ATP sensitive potassium channels (K ATP ) have been thought to be a mediator of cardioprotection. Recent pharmacologic and molecular biology studies show the protective effects of K ATP openers are not dependent of action potential shortening and cardiodepressant effects, but mediated by preservation of mitochondrial function, which suggests a role for intracellular mitochondrial K ATP (mito K ATP ). The mechanism by opening mito K ATP produces cardioprotection is less clearer, however, it is thought that a beneficial effect may occur as the result of K + entry and intramitochondrial depolarization. This effect would reduce mitochondrial calcium overload and cause matrix swelling, which are shown to enhance ATP synthesis and stimulate mitochondrial respiration.
