Lipopolysaccharide-induced liver injury expression Kupffer cell and protection mechanisms of S-adenosylmethionine
10.3760/cma.j.issn.1673-4203.2009.12.021
- VernacularTitle:内毒素诱导Kupffer细胞所致肝脏损害及S-腺苷蛋氨酸的保护机制
- Author:
Zhao ZHANG
;
Jianping GONG
- Publication Type:Journal Article
- Keywords:
s-adennsylmethionine(SAM);
kupffer cell(KC);
lipopolysaccharide(LPS)
- From:
International Journal of Surgery
2009;36(12):846-849,封3
- CountryChina
- Language:Chinese
-
Abstract:
S-adenosylmethionine(SAM) is a physiologically active molecule in all the organizations and the human body fluids, and it is important to participate in a variety of biochemical reactions, the regulation of liver regeneration, liver cells differentiation and various sensitivity of the injury. The SAM affects the liver through a variety of ways. It is confirmed that the SAM and MTA can block the LPS-induced TNF-α of Kupffer cells to protect the liver. In a word, S-adenosylmethionine may be beneficial to LPS-induced liver in-jury in clinical treatment.
