Recombinant human augmenter of liver regeneration may promote stromelysin-1 gene expression in experimental liver fibrosis
- VernacularTitle:重组人肝再生增强因子可促进实验性肝纤维化基质分解素-1的基因表达
- Author:
Aimin WANG
;
Baozhong LIANG
;
Xiaoming YANG
- Publication Type:Journal Article
- Keywords:
Recombinant human augmenter of liver regeneration;
Stromelysin 1;
Gene expression
- From:
Chinese Journal of Infectious Diseases
2001;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of recombinant human augmenter of liver rege neration (hALR) on stromelysin 1 gene expression in experimental liver fibrosis. Methods Two kinds of rat model of experimental liver fibrosis induced by CCl 4 and albumin were established and different dosages of recombinant human augmenter of liver regeneration were given during the process of model making. Total RNA of liver tissues was extracted and stromelysin 1 gene expression levels were measured by reverse transcription polymerase chain reaction (RT PCR). Results In both rat models of experimental liver fibrosis, stromelysin 1 gene expression levels in hALR treating group were significantly higher than those of model groups in different periods of model forming. Stromelysin 1 gene expression levels in high dose hALR treated group were significantly higher than those of low dose hALR treated group.Conclusion Recombinant human augmenter of liver regeneration may have effects of promoting gene expression of stromelysin 1 in experimental liver fibrosis.
