EFFECTS OF ?-CAROTENE ON THE STABILITY OF RBC-MEMBRANE STRUCTURE IN RATS
- VernacularTitle:?-胡萝卜素对大鼠红细胞膜结构稳定性的影响
- Author:
Huiqin SHEN
;
Ying GAO
- Publication Type:Journal Article
- Keywords:
carotene;
vitamin E;
RBC-membrane;
lipid peroxidation;
RBC-membrane fluidity
- From:
Acta Nutrimenta Sinica
1956;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the effect of ?- carotene(?-C) on lipid peroxidation and RBC-membrane fluidity of rats inflicted with alloxan. Methods: Forty-four 2mo-old Wistar rats were randomly divided into 4 groups and fed with basal diet (group A and B), basal diet + vitamin E (200 mg/kg) (C) and basal diet+? carotene (200 mg/kg) (D) for 4 w respectively. Then, alloxon (3%) was injected intraperitoneally except group A, which was injected with normal saline. After 48 h the rats were killed and a series of indices were examined. Results: After injected with alloxan, Na +,K +-ATPase and GSH-Px activity, RBC-membrane fluidity in rats fed with diets C,D were markedly increased while MDA levels were decreased. Conclusion: ?-C and V E can decrease lipid peroxidation and increase the stability of RBC-membrane in rats inflicted with alloxan.
