EFFECT OF MAGNESIUM SUPPLEMENTATION ON H_2O_2-INDUCED OXIDATIVE DNA DAMAGE OF CULTURED HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS
- VernacularTitle:镁对人脐静脉内皮细胞DNA氧化损伤的影响
- Author:
Xiaohua LU
;
Ruishu WANG
- Publication Type:Journal Article
- Keywords:
magnesium;
human umbilical vein endothelial cells;
oxidative DNA damage
- From:
Acta Nutrimenta Sinica
1956;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the effect of Mg 2+ on oxidative DNA damage of cultured human umbilical vein endothelial cells. Methods: The single-cell gel electrophoresis was used to determine the frequencies of cells with tail moment (TM) and the tail lengths. Results: The supplementation of Mg 2+ in the incubation medium influenced the H 2O 2-induced oxidative DNA damage. When compared with the group of H 2O 2, the frequencies of cells with TM and the tail lengths were markedly decreased in the group of H 2O 2+Mg 2+ at all doses (P
