THE THERAPEUTIC EFFECT OF GINGER OLEORESINS ON HYPERLIPIDEMIA AND PLATELET AGGREGATION
- VernacularTitle:姜油树脂调节血脂和抗血小板聚集作用的研究
- Author:
Yan CHEN
;
Ze TIAN
;
Yiqiang GE
;
Tongyi CAI
- Publication Type:Journal Article
- Keywords:
Ginger oleoresin;
platelet aggregation;
blood lipid;
hyperlipidemia
- From:
Acta Nutrimenta Sinica
1956;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the effects of ginger oleoresins(GO) on blood lipids in hyperlipidemic mice and the platelet aggregation in rats.Methods: The rat platelet aggregation was induced by ADP and AA in vitro, and the inhibition by GO was tested by light transmission. The animal model of hyperlipidemia was establised by feeding Kunmimg mice with high lipid feed stuff. The effects of GO on serum lipid and hepatic MAD in hyperlipidemic mice was investigated. Results: GO could effectively inhibit rat platelet aggregation induced by ADP and AA in vitro, which were 58.9%,97.5% respectively, and in dose dependant manner. Besides, GO could also significantly decrease serum TC, LDL, AS index and hepatic MDA in hyperlipidemic mice, which were 16.45%, 60.45%,37.30% and 54.27% respectively, and showed no side-effect on liver. Conclusion: Long-term consumption of GO can effectively modulate blood lipids, prevent thrombosis and AS.
