SPECIAL ATTENTION SHOULD BE GIVEN TO THE RESEARCH ON EXTRACELLULAR MATRIX DEGRADATIVE SYSTEMS IN KIDNEY DISEASES
- VernacularTitle:细胞外基质降解酶系统在肾脏疾病中作用的研究
- Author:
Xiangmei CHEN
- Publication Type:Journal Article
- Keywords:
kidney diseases;
extracellular matrix degrading enzymes;
matrix metalloproteinases;
plasminogen activators
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(12):-
- CountryChina
- Language:Chinese
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Abstract:
Alterations in the balance between synthesis and degradation of extracellular matrix (ECM) and its remodeling may result in an accumulation of ECM molecules and lead to glomerulosclerosis. Recent studies have focused on the role of degradative systems, especially the roles of plasminogen activators/plasminogen activator inhibitors (PA/PAI), matrix metalloproteinases, and their inhibitors[GK2*4/5!2*4/5] (MMP/TIMP) in the initiation and pathogenesis of renal diseases. Previously, attention has been paid to the study of inhibitors of ECM degrading enzymes, such as PAI and TIMP. Recent researchs showed that there existed complex dynamic expressions of enzymes and their inhibitors. Although many studies have tried to elucidate the pathogenesis of renal diseases, the exact underlying mechanisms are still not completely understood. For better understanding of the mechanism of chronic progressive renal diseases, the underlying genetic and molecular regulation of each component of PA/PAI and MMP/TIMP systems should be elucidated in different renal physiological and pathophysiological processes. Future studies are needed to manipulate activity or expression of these proteinases in order to treat and/or prevent glomerular diseases.
