EFFECTS OF ANTISENSE OLIGONUCLEOTIDES DIRECTED AT TNE-? ON THE INTRACRANIAL PRESSURE IN DOGS FOLLOWING CRANIOCEREBRAL EXPLOSIVE INJURY
- VernacularTitle:TNF-?反义寡核苷酸对犬颅脑爆炸伤后颅内压的影响
- Author:
Lijun HOU
;
Yicheng LU
;
Guangj ZHANG
- Publication Type:Journal Article
- Keywords:
explosive wound;
tumor necrosis factor;
oligonucleotides, antisense;
brain edema;
intracranial pressure
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the effects of antisense oligonucleotides directed at TNF-? on the intracranial pressure following craniocerebral explosive injury. Eighteen dogs were randomly divided into artificial cerebrospinal fluid (ACSF) group, sense group and antisense group. Using the model of craniocerebral explosive injury, ACSF, the sense oligonucleotides to TNF-? and the antisense oligonucleotides to TNF-? were administered into cerebellomedullar cisterna before injury respectively in three groups, and then the intracranial pressure and contents of brain H 2 O in the bilateral hemispheres in three groups were compared. As compared with the ACSF groups and the sense groups, the contents of brain H 2 O in the antisense groups were significantly reduced( P
